The cofilin activity cycle in lamellipodia and invadopodia
نویسندگان
چکیده
منابع مشابه
Invadopodia: RhoC Runs Rings around Cofilin
Tumor cell invadopodia mediate degradation of matrix barriers. A new study now demonstrates that a ring of active RhoC focuses invadopodial protrusion and degradation by regulating cofilin activity.
متن کاملImaging Sites of N-WASP Activity in Lamellipodia and Invadopodia of Carcinoma Cells
Cell migration is crucial for many biological and pathological processes such as chemotaxis of immune cells, fibroblast migration during wound healing, and tumor cell invasion and metastasis. Cells migrate forward by extending membrane protrusions. The formation of these protrusions is driven by assembly of actin filaments at the leading edge. Neural Wiskott-Aldrich syndrome protein (N-WASP), a...
متن کاملA pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia
Cofilin mediates lamellipodium extension and polarized cell migration by stimulating actin filament dynamics at the leading edge of migrating cells. Cofilin is inactivated by phosphorylation at Ser-3 and reactivated by cofilin-phosphatase Slingshot-1L (SSH1L). Little is known of signaling mechanisms of cofilin activation and how this activation is spatially regulated. Here, we show that cofilin...
متن کاملA Novel Spatiotemporal RhoC Activation Pathway Locally Regulates Cofilin Activity at Invadopodia
BACKGROUND RhoGTPases have been implicated in the regulation of cancer metastasis. Invasive carcinoma cells form invadopodia, F-actin-rich matrix-degrading protrusions that are thought to be important for tumor cell invasion and intravasation. Regulation of actin dynamics at invadopodial protrusions is crucial to drive invasion. This process requires the severing activity of cofilin to generate...
متن کاملA common cofilin activity cycle in invasive tumor cells and inflammatory cells.
In many cell types, the formation of membrane protrusions and directional migration depend on the spatial and temporal regulation of the actin-binding protein cofilin. Cofilin, which is important for the regulation of actin-polymerization initiation, increases the number of actin free barbed ends through three mechanisms: its intrinsic actin-nucleation activity; binding and severing of existing...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2009
ISSN: 0730-2312,1097-4644
DOI: 10.1002/jcb.22372